Vacuum dryer for pharmaceutical intermediates

Pharmaceutical intermediates material characteristics

Pharmaceutical intermediates, in fact, are some chemical raw materials or chemical products used in the process of drug synthesis, such chemical products, which do not need the production license of drugs, can be produced in ordinary chemical plants, as long as they reach the level of some of them, can be used in the synthesis of drugs.

Pharmaceutical intermediates dryer equipment characteristics

Double cone rotary vacuum dryer is a drying equipment integrating mixing and vacuum drying. The process of vacuum drying is to put the material to be dried in the sealed cylinder, use the vacuum system to pump the vacuum at the same time to heat the material to be dried, so that the water inside the material diffuses to the surface through the difference of pressure or concentration, the water molecules (or other non-condensable gases) get enough kinetic energy on the surface of the material, and diffuse to the low-pressure space of the vacuum chamber after overcoming the molecular attraction, and then be pumped away by the vacuum pump to accomplish the separation of the material from the solids. Separation of solids. Therefore, double cone rotary vacuum dryer shows the following characteristics:

(1) In the process of vacuum drying, the pressure inside the cylinder is always lower than the atmospheric pressure, the number of gas molecules is less, the density is low, the oxygen content is low, so it can dry the medicine which is easy to be oxidized, and reduce the chance of the material dyeing bacteria.

(2) Due to the wetness in the process of vaporization temperature and steam pressure is proportional to the vacuum drying, so the wetness in the material can be vaporized at low temperature to achieve low-temperature drying, especially suitable for the production of pharmaceuticals with heat-sensitive materials.

(3) Vacuum drying can eliminate the surface hardening phenomenon which is easy to be produced by normal pressure hot air drying, this is because the vacuum drying material and the surface of the pressure difference between the material is large, under the action of pressure gradient, the moisture will move to the surface very quickly, and there will be no surface hardening.

(4) Due to the vacuum drying, the temperature gradient between the material inside and outside is small, due to the reverse osmosis effect makes the moisture can move alone and collect, effectively overcome the phenomenon of dispersion produced by hot air drying.

Theory shows that the equipment also has the following characteristics: (1) the heating temperature is constant, increase the vacuum degree, the rate is accelerated; (2) the vacuum degree is constant, increase the heating temperature, the rate is accelerated; (3) both to improve the vacuum degree, but also to improve the heating temperature, the rate is greatly accelerated. (4) The heating medium can be hot water or steam (steam pressure at 0.40-0.50Mpa); (5) The inner wall of the dryer adopts arc transition to avoid health dead ends and solvent condensation and condensation dripping to a layer of contaminant flow in the material tray.

Pharmaceutical intermediates double cone rotary vacuum dryer advantages

The machine is simple to operate, easy to enter and exit the material, greatly reducing the labor intensity of workers, and also reduces the material in the drying process by the environmental pollution, improve product quality, in line with the drug management standard “GMP” requirements.